Dr. Hui-Yi Lin Publishes High-Impact Study in Communications Medicine, a Nature Portfolio Journal, Advancing Prediction of Prostate Cancer Aggressiveness

June 17, 2026

Dr. Hui-Yi Lin, Professor of the Biostatistics & Data Science Program at LSU Health Sciences Center (LSUHSC), in collaboration with an international, multi-institutional research team, has developed a novel polygenic risk score that incorporates KLK3 gene–gene interactions to enhance the prediction of prostate cancer aggressiveness. Published in a high-impact, peer-reviewed journal and funded by the U.S. Department of Defense (DOD), this work addresses a critical gap in risk stratification for this highly heterogeneous disease. The proposed risk score was developed using novel statistical methods developed by Dr. Lin’s team and validated using the large-scale international consortium genetic dataset across multiple study sites. The results showed that this score can significantly outperform the existing genetic risk tools. By leveraging interactions of inherited genetic variants, primarily in KLK3, the gene encoding prostate-specific antigen (PSA), this study boosts predictive accuracy and reveals key links to disease severity. Ultimately, these findings lay the groundwork for precision medicine for guiding early screening, enabling earlier detection, and improving clinical decision-making. 

🔗 Read the full paper: https://www.nature.com/articles/s43856-026-01645-z