Title: Efficient Large Design Space Exploration and Prediction in Computer Microarchitectural Study Authors: Bin Li, Lu Peng and Balachandran Ramadass Abstract: Computer architects usually use cycle-by-cycle simulation to evaluate design choices and understand tradeoffs (between processor performance and power consumption) and interactions among design parameters. Efficiently exploring the exponential-size design spaces with many interacting parameters remains an open problem: the sheer number of experiments renders detailed simulation intractable. However, only configurations in a subspace can be simulated in practice due to long simulation time and limited resource, leading to suboptimal conclusions which might not be applied to a larg-er design space. In this study, we propose an automated design space exploration and prediction method which employs sampling technique from experiment design and machine learning, and predictive modeling in data mining. Results shown that our method not only produces highly accurate estimation for unsampled points in the design space, but also provides interpretation tools that help investigators to understand performance bottlenecks.